Sortilin as a Biomarker for Cardiovascular Disease Revisited
نویسندگان
چکیده
منابع مشابه
DNA Methylation as a Biomarker for Cardiovascular Disease Risk
BACKGROUND Elevated serum homocysteine is associated with an increased risk of cardiovascular disease (CVD). This may reflect a reduced systemic remethylation capacity, which would be expected to cause decreased genomic DNA methylation in peripheral blood leukocytes (PBL). METHODOLOGY/PRINCIPAL FINDINGS We examined the association between prevalence of CVD (myocardial infarction, stroke) and ...
متن کاملSortilin and the risk of cardiovascular disease.
Plasma low-density lipoprotein cholesterol (LDL-C) levels are a key determinant of the risk of cardiovascular disease, which is why many studies have attempted to elucidate the pathways that regulate its metabolism. Novel latest-generation sequencing techniques have identified a strong association between the 1p13 locus and the risk of cardiovascular disease caused by changes in plasma LDL-C le...
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Introduction: MicroRNAs are small, non-coding, and protected RNA molecules that regulate gene expression after transcription by mRNA degradation or inhibition of protein synthesis. The function of these molecules is critical to many cellular processes, including growth, development, differentiation, homeostasis, apoptosis, aging, stress resistance. In addition, some diseases including cancer, a...
متن کاملCirculating sortilin level as a potential biomarker for coronary atherosclerosis and diabetes mellitus
CONTEXT A previous genome-wide association study showed that a genetic variant of sortilin was associated with the risk of coronary artery disease (CAD). However, the role of circulating sortilin is still unknown. We investigated the potential role of plasma sortilin as a biomarker for CAD and diabetes mellitus. METHODS We enrolled statin-naïve subjects with CAD (n = 31) who underwent coronar...
متن کاملAs a Biomarker for Alzheimer Disease
The search is ongoing for a reliable serum biomarker for AD. The level of iron is elevated in the brain of Alzheimer’s disease (AD) patients. Our studies have demonstrated that the level of the iron transport protein, p97, is increased in the serum of AD patients but not in various control groups. These results have recently been confirmed by another laboratory who extended our findings by demo...
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ژورنال
عنوان ژورنال: Frontiers in Cardiovascular Medicine
سال: 2021
ISSN: 2297-055X
DOI: 10.3389/fcvm.2021.652584